Hepatitis B vaccine immunogenicity in Kerman 12 months infants

Introduction: Infection  with  HBV  is  the  most  common  chronic  viral  infection  and mortality  in  children.  Prevention of this infection with vaccination is vital.  This  study  was  done  to compare  the  antibody  level  in post hepatitis  B vaccination  in  children  with  12 months  age. Materials  and  Methods:This  descriptive  study  was  carreid  out  on healthy  120  children  with  12 months  age  who  had  notinfected  with  hepatitis  B  infection  in,  kerman  Iran  during 2014. gender, body  weight,  birth  weight, gestational  age  were  recorded  for  each  child.  Hepatitis  B  antibody  level  was  measured  with  ELISA method.  Data were  analyzed  using  SPSS-16 . Results: Antibody  level  was  high- protective for  %81.7  of children , low-responders for %13.3 and no-protective level for %13.3 of children in our study.For % 86.9 children over 2500 kg of birth weight the Antibody  level  was  highly protective incoparison with %57.1 of under 2500 kg of birth weight. This  differnce  was significant.Ther was no significantly  corrolated  with  gender,bodyweight,gestational  age  and  Antibody  level.The family history for hepatitis B infection was negetive for all samples. Conclusion:  This  study  showed  that  the  %95 of children have adequate levels of anti-HBs (≥ 10 IU/L) after vaccination.in addition, immune response was higher in normal birth weight children. Introduction: Infection  with  HBV  is  the  most  common  chronic  viral  infection  and mortality  in  children.  Prevention of this infection with vaccination is vital.  This  study  was  done  to compare  the  antibody  level  in post hepatitis  B vaccination  in  children  with  12 months  age. Materials  and  Methods:This  descriptive  study  was  carreid  out  on healthy  120  children  with  12 months  age  who  had  notinfected  with  hepatitis  B  infection  in,  kerman  Iran  during 2014. gender, body  weight,  birth  weight, gestational  age  were  recorded  for  each  child.  Hepatitis  B  antibody  level  was  measured  with  ELISA method.  Data were  analyzed  using  SPSS-16 . Results: Antibody  level  was  high- protective for  %81.7  of children , low-responders for %13.3 and no-protective level for %13.3 of children in our study.For % 86.9 children over 2500 kg of birth weight the Antibody  level  was  highly protective incoparison with %57.1 of under 2500 kg of birth weight. This  differnce  was significant.Ther was no significantly  corrolated  with  gender,bodyweight,gestational  age  and  Antibody  level.The family history for hepatitis B infection was negetive for all samples. Conclusion:  This  study  showed  that  the  %95 of children have adequate levels of anti-HBs (≥ 10 IU/L) after vaccination.in addition, immune response was higher in normal birth weight children.